Author

Feifei Zhang

Shanghai Medical College of Fudan University

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Biology Disciplines

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Cancer Biology· 2 Bioinformatics· 1 Genetics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Assay:bulk RNA-seq· 3 Research Focus:drug response / drug discovery· 3 Approach:statistical model· 3 Approach:deep learning· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Chuanpeng DongiD· 2 shared Hongwu Yu· 2 shared Nipun VermaiD· 2 shared Peng LiniD· 2 shared Qiaojuan Li· 2 shared Sidi CheniD· 2 shared Yan LiiD· 2 shared Yifan Wen· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBioinformatics

Chuanpeng DongORCID

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Author profile →

5 papers

Recent·Most cited

Harnessing Tumor-Specific Transcript Diversity Uncovers a Shared Neoantigen Reservoir for Pancreatic Ductal Adenocarcinoma

Jingjing Zhao, Qiaojuan Li, Peng Lin, Yu Yang, Hongwu Yu, Yifan Wen, Wenqian Yu, Huiyi He, Sichen Tao, Feifei Zhang, Yan Li, Zhixiang Hu, Jing Xie, Zhen Chen, Shenglin Huang

This paper introduces NeoAPP, a tool to identify tumor-specific transcript-derived neoantigens in PDAC, revealing a large neoantigen reservoir that could improve immunotherapy.

MedComm · Jul 30, 2026Peer-reviewedCancer Biology

Decoding Neoantigen-encoding Tumor-Specific Transcripts Unveils a Shared Target Reservoir for Immunotherapy in Hepatocellular Carcinoma

Peng Lin, Yifan Wen, Jingjing Zhao, Feifei Zhang, Yaoming Su, Hongwu Yu, Yu Hx, Qiaojuan Li, Chengye Liu, Zhixiang Hu, Yan Li, Zhuting Fang, Linhui Liang, Shenglin Huang

This paper identifies neoantigen-encoding tumor-specific transcripts (neoTSTs) in hepatocellular carcinoma, showing they are more abundant and immunogenic than mutation-derived neoantigens, and demonstrate therapeutic potential in preclinical models.

Journal for ImmunoTherapy of Cancer · Jul 1, 2026Peer-reviewedCancer Biology

TCPGdb: A comprehensive T cell perturbation genomics database for identification of critical T cell regulators

Chuanpeng Dong, Feifei Zhang, Kaiyuan Tang, Nipun Verma, Xinxin Zhu, Di Feng, James Cai, Hongyu Zhao, Sidi Chen

The paper introduces TCPGdb, a database integrating T cell perturbation screens to identify critical regulators of T cell function and anti-tumor persistence.

Cancer Immunology Research · Nov 21, 2025Peer-reviewedBioinformatics

Cholesterol esterification blockade boosts immunotherapy and reduces liver cancer relapse

Yange Gu, Lulu Zhang, Jianhua Li, Ensi Ma, Weiwei Hu, Xiaocheng Du, Feifei Zhang, Tiange Yang, Linyue Bian, Yitian Jin, Yun Liu, Yinghua Wang, Zihan Ning, Chune Yu, Dun Li, , Guangchuan Wang

This study identifies SOAT1 as a target for improving immunotherapy and reducing liver cancer relapse by blocking cholesterol esterification.

bioRxiv · Oct 15, 2025 · PreprintImmunology

Genome scale CRISPR screens identify actin capping proteins as key modulators of therapeutic responses to radiation and immunotherapy

Xin Shan, Paul A. Renauer, Chuanpeng Dong, Yanzhi Feng, Ping Ren, Qianqian Lin, Feifei Zhang, Narges Tafreshi, Peter M. Glazer, Sidi Chen, Nipun Verma

The paper identifies actin capping proteins as key modulators of therapeutic responses to radiation and immunotherapy through genome-scale CRISPR screens in melanoma cells.

bioRxiv · Jan 14, 2024 · PreprintGenetics