Author

Yifan Wen

Shanghai Medical College of Fudan University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Bioengineering· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Approach:deep learning· 3 Organism:human· 3 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

Hongwu Yu· 4 shared Peng LiniD· 4 shared Shenglin HuangiD· 3 shared Yan LiiD· 3 shared Chengye LiuiD· 2 shared Feifei Zhang· 2 shared Qiaojuan Li· 2 shared Zhixiang HuiD· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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4 shared papersCancer Biology

Hongwu Yu

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Harnessing Tumor-Specific Transcript Diversity Uncovers a Shared Neoantigen Reservoir for Pancreatic Ductal Adenocarcinoma

Jingjing Zhao, Qiaojuan Li, Peng Lin, Yu Yang, Hongwu Yu, Yifan Wen, Wenqian Yu, Huiyi He, Sichen Tao, Feifei Zhang, Yan Li, Zhixiang Hu, Jing Xie, Zhen Chen, Shenglin Huang

This paper introduces NeoAPP, a tool to identify tumor-specific transcript-derived neoantigens in PDAC, revealing a large neoantigen reservoir that could improve immunotherapy.

MedComm · Jul 30, 2026Peer-reviewedCancer Biology

Decoding Neoantigen-encoding Tumor-Specific Transcripts Unveils a Shared Target Reservoir for Immunotherapy in Hepatocellular Carcinoma

Peng Lin, Yifan Wen, Jingjing Zhao, Feifei Zhang, Yaoming Su, Hongwu Yu, Yu Hx, Qiaojuan Li, Chengye Liu, Zhixiang Hu, Yan Li, Zhuting Fang, Linhui Liang, Shenglin Huang

This paper identifies neoantigen-encoding tumor-specific transcripts (neoTSTs) in hepatocellular carcinoma, showing they are more abundant and immunogenic than mutation-derived neoantigens, and demonstrate therapeutic potential in preclinical models.

Journal for ImmunoTherapy of Cancer · Jul 1, 2026Peer-reviewedCancer Biology

Engineering Linear Cap-independent mRNA Vaccines with Intrinsic Adjuvanticity for Potent Cancer Immunotherapy

Hongwu Yu, Yu Yang, Peng Lin, Chengye Liu, Yifan Wen, Zhuting Fang, Zhixiang Hu, Shenglin Huang

This paper develops a cap-independent mRNA vaccine platform that enhances antitumor immunity through intrinsic adjuvanticity and improved in vivo expression.

bioRxiv · Oct 27, 2025 · PreprintBioengineering

Transcriptomic splicing analysis reveals a gene-independent form of TE reactivation in tumors representing unrecognized source of oncogenes and neoantigens

Ziteng Li, Yichao Bao, Qin Li, Hongwu Yu, Hena Zhang, Yifan Wen, Yu Yang, Jingjing Zhao, Peng Lin, Yan Li, Zhixiang Hu, Xichun Hu, Xiaodong Zhu, Shenglin Huang

This paper identifies TEtrans, gene-independent transcripts from transposable elements in tumors, which act as oncogenes and neoantigens, expanding the role of TEs in cancer.

bioRxiv · Mar 1, 2025 · PreprintCancer Biology

JWA deficiency accelerates aging through disrupting intestinal epithelial homeostasis via Notch1/PPARγ/Stat5 axis

Xiong Li, Jingwen Liu, Luman Wang, Yan Zhou, Yifan Wen, Kun Ding, Lu Zou, Xia Liu, Aiping Li, Yun Wang, Heling Fu, Min Huang, Guoxian Ding, Jianwei Zhou

This study identifies JWA as an aging-associated gene whose deficiency disrupts intestinal epithelial homeostasis and accelerates aging in mice through the Notch1/PPARγ/Stat5 axis.

bioRxiv · Jan 17, 2022 · PreprintDevelopmental Biology