Insulated expression of periplasmic uricase in E. coli Nissle 1917 for the treatment of hyperuricemia
Lina He, Wei Tang, Ling Huang, Wei Zhou, Shaojia Huang, Linxuan Zou, Lisha Yuan, Dong Men, Shiyun Chen, Yangbo Hu
This study engineered an E. coli probiotic to express periplasmic uricase in an insulated site, showing efficacy in reducing hyperuricemia in animal models without affecting probiotic properties.
bioRxiv · Apr 17, 2022 · PreprintSynthetic Biology