Wei Tang

This study engineered an E. coli probiotic to express periplasmic uricase in an insulated site, showing efficacy in reducing hyperuricemia in animal models without affecting probiotic properties.

Baicalin and baicalein from Scutellaria baicalensis inhibit SARS-CoV-2 3CL protease non-covalently; a 2.2 Å baicalein complex structure shows an unusual shield-like binding mode.

This study shows that reduced gene dosage in multiple genes causes multisystem disorders in DM1 by creating mouse models with multigene mutations.