Engineered Cpf1 Enzymes with Altered PAM Specificities
Linyi Alex Gao, David B.T. Cox, Winston X. Yan, John C. Manteiga, Martin Schneider, Takashi Yamano, Hiroshi Nishimasu, Osamu Nureki, Nicola Crosetto, Feng Zhang
This paper engineers Cpf1 variants with altered PAM specificities to expand their targeting range while maintaining specificity.
Nature Biotechnology · Jun 5, 2017Peer-reviewedSynthetic Biology