Yinqing Li

This study shows that NFI proteins regulate radial glial progenitor lifespan and output in a dose-dependent manner, affecting neocortical development and causing malformations in human cerebral organoids and mouse models.

The paper identifies a two-layered regulatory network governing temporal patterning in neocortical development through single-cell multi-omics analysis.

scDecouple separates true cellular response from gRNA infection bias in scCRISPR-seq data, improving gene perturbation analysis in heterogeneous samples.

ExSeq enables multiplexed RNA mapping at nanoscale resolution by expanding biological specimens for in situ sequencing.

BLISS quantifies DNA double-strand breaks in situ with high sensitivity and efficiency, showing Cpf1 has higher specificity than Cas9.

Div-Seq tracks transcriptional dynamics of rare adult newborn neurons using single nucleus RNA-Seq and EdU labeling.