Mesocorticolimbic circuit mechanisms underlying the effects of ketamine on dopamine: a translational imaging study
Michelle Kokkinou, Elaine E. Irvine, David R. Bonsall, Sridhar Natesan, Lisa A. Wells, Mark Smith, Justyna A. Glegola, Eleanor J. Paul, Kyoko Tossell, Mattia Veronese, Sanjay P. Khadayate, Nina Dedic, Seth C. Hopkins, Mark A. Ungless, Dominic J. Withers, Oliver David Howes
This study shows that sub-chronic ketamine in mice increases striatal dopamine synthesis and locomotor activity, which can be reversed by targeting PV interneurons and TAAR1.
bioRxiv · Sep 1, 2019 · PreprintNeuroscience