Eleanor J. Paul

This study shows that a single cocaine exposure causes long-lasting 3D genome structure changes in midbrain dopamine neurons, affecting gene regulation and synaptic plasticity.

The paper investigates cell-type specific 3D chromatin structures in the brain using immunoGAM, finding TAD melting, neuron-specific contacts, and compartmentalization patterns related to gene expression and neurodegenerative diseases.

This study shows that sub-chronic ketamine in mice increases striatal dopamine synthesis and locomotor activity, which can be reversed by targeting PV interneurons and TAAR1.

The paper identifies nNOS-expressing neurons in the VTA and SNc as either GABAergic local interneurons or glutamatergic projection neurons, depending on their sub-region.