Dominic J. Withers

This study investigates the human Glp1r A316T variant's effects on glucose metabolism and GLP-1RA responses using mouse models and structural analyses.

This study shows GLP-1R agonists improve mitochondrial health in beta-cells by forming a complex with VAPB and SPHKAP at ER-mitochondria MCSs, leading to mitochondrial remodelling and improved function.

This study shows that inhibiting IL11 improves healthspan in aged mice by reversing metabolic dysfunction, sarcopenia, and frailty.

This study identifies fetal and maternal GDF15 as key factors in pregnancy-related nausea and vomiting, showing their roles in disease risk and severity.

This study identifies male-specific brain aging improvements from reduced neuronal insulin signaling in mice.

This study investigates the role of C2cd4b in murine glucose homeostasis, revealing sexually dimorphic effects on body weight and glucose tolerance.

This study shows that sub-chronic ketamine in mice increases striatal dopamine synthesis and locomotor activity, which can be reversed by targeting PV interneurons and TAAR1.

The paper identifies nNOS-expressing neurons in the VTA and SNc as either GABAergic local interneurons or glutamatergic projection neurons, depending on their sub-region.