Evolutionary trajectories determine the feasibility of collateral sensitivity based antibiotic treatment strategies in critical bacterial pathogens
Vatsala Chauhan, Lisa Enkvist, Yuliia Chukhareva, Carl Damell, Eric Cruz Davila, Tasnim M. Islam, Greta Melander, Ellen Paulsson, Adam Sundell, Emily Zweifel, Anna af Klercker, Anna Knöppel, Gerrit Brandis
This study investigates collateral sensitivity in bacterial pathogens, finding that resistance mutations can sometimes increase susceptibility to other antibiotics, but these mutations are often costly and not present in clinical isolates.
Communications Biology · Dec 6, 2025Peer-reviewedMicrobiology