Vatsala Chauhan

Evolutionary trajectories determine the feasibility of collateral sensitivity based antibiotic treatment strategies in critical bacterial pathogens

This study investigates collateral sensitivity in bacterial pathogens, finding that resistance mutations can sometimes increase susceptibility to other antibiotics, but these mutations are often costly and not present in clinical isolates.

Thermal shifts can override the effects of Transcription-targeting Antibiotics

The paper shows that thermal shifts override antibiotic effects in E. coli by altering transcriptomes and physiological responses across multiple levels.

Dynamics of bacterial operons during genome-wide stresses is influenced by premature terminations and internal promoters

The paper investigates how premature terminations and internal promoters affect operon responses during genome-wide stresses in bacteria.

Transcription attenuation in synthetic promoters in tandem formation

The paper studies transcription attenuation in synthetic tandem promoters in E. coli, finding that promoter positioning and factors like rifampicin influence attenuation through RNAP collisions.

A library of reporters of the global regulators of gene expression of Escherichia coli

The paper develops a library of fluorescent reporters for 16 global regulators in E. coli to track their activity under various growth and stress conditions.

Sequence-dependent model of genes with dual σ factor preference

The paper models gene promoters with dual σ factor preference in E. coli, showing sequence-dependent sensitivity to σ70 and σ38 and proposing a generalizable framework for synthetic biology applications.

The transcription factor network of E. coli steers global responses to shifts in RNAP concentration

The paper examines how changes in RNA polymerase concentration affect gene expression in E. coli, finding that mid-term responses correlate with transcription factor network topology.

Analytical kinetic model of native tandem promoters in E. coli

The paper develops an analytical model of gene expression dynamics for tandem promoters in E. coli, showing that transcription interference depends on RNAP occupancy time and distance between transcription start sites.

Positive supercoiling buildup is a trigger of E. coli's short-term response to cold shock

The paper identifies cold shock repressed genes in E. coli and shows their responsiveness is linked to positive supercoiling buildup and Gyrase inhibition.