US6 hijacks the peptide-loading complex by trapping transporter-chaperone dynamics
Milena Stolz, Lukas Sušac, Amin Fahim, Rieke Keller, Lisa Saggau, Filippo Mancia, Simon Trowitzsch, Robert Tampé
This paper reveals how the HCMV protein US6 inhibits the peptide-loading complex by altering TAP dynamics, providing insights into viral immune evasion mechanisms.
bioRxiv · Jun 25, 2025 · PreprintImmunology