The single amino acid change of R516K enables efficient generation of vesicular stomatitis virus-based Crimean-Congo hemorrhagic fever reporter virus
Xue Ma, Yanlong Ma, Ziqiao Wang, Fei Feng, Yutong Han, Xinran Sun, Liushuai Li, Zhichao Gao, Manli Wang, Rong Zhang
The paper introduces a recombinant vesicular stomatitis virus with CCHFV glycoprotein and EGFP reporter, enabling high-titer pseudovirus packaging through a single amino acid mutation.
Journal of Medical Virology · Jun 1, 2025Peer-reviewedMicrobiology