Zhichao Gao

UHRF1 restricts HCoV-229E infection through epigenetic silencing of the viral receptor APN

This study identifies UHRF1 as a host factor that restricts HCoV-229E infection by epigenetically silencing its receptor APN, with age-related UHRF1 decline linked to increased viral susceptibility.

DAZAP2 functions as a pan-coronavirus restriction factor by inhibiting viral entry and genomic replication

This study identifies DAZAP2 as a pan-coronavirus restriction factor that inhibits viral entry and genomic replication, with physiological relevance confirmed in mouse models and human cells.

The single amino acid change of R516K enables efficient generation of vesicular stomatitis virus-based Crimean-Congo hemorrhagic fever reporter virus

The paper introduces a recombinant vesicular stomatitis virus with CCHFV glycoprotein and EGFP reporter, enabling high-titer pseudovirus packaging through a single amino acid mutation.

Glycosylphosphatidylinositol biosynthesis restricts coronavirus infection via the regulation of LY6E

This study identifies GPI biosynthesis as a conserved host restriction factor against coronaviruses, with LY6E as a key antiviral effector.