Bacterial suppression of intestinal fungi via activation of human gut γδ T-cells
Liya Mathew, Sean Carlson, Michael Savage, Claire Pardieu, Megan O’Brien, Ellie Crawley, Paul Harrow, Ann-Kristin Kaune, Edward Devlin, Emily L. Priest, Marilena Crescente, Kimberly Martinod, James R. Boot, Marco Gasparetto, Klaartje Bel Kok, , Neil E. McCarthy
The paper shows that bacterial metabolite HMB-PP activates human gut γδ T-cells to suppress fungal growth, but this mechanism is impaired in Crohn's disease.
bioRxiv · Sep 17, 2025 · PreprintImmunology