Structure-guided discovery and engineering of miniature CRISPR-Cas12m for epigenome editing
Tao Yu, Meng Ji, Donglin Yu, Zhao Guan, Rongyi Zhu, Yupeng Jiang, Zhiyi Yang, Lizhen Qiu, Ziyi Zhang, Jiawei Mu, Fengbiao Mao, Kuanhui Xiang, Lin Bai, Kailong Li
This paper identifies and engineers a miniature CRISPR-Cas12m variant for epigenome editing, demonstrating its effectiveness in human cells and a mouse model of HBV infection.
Nature Structural & Molecular Biology · Sep 16, 2026Peer-reviewedBioengineering