Uncovering nick DNA binding by LIG1 at the single-molecule level
Surajit Chatterjee, Loïc Chaubet, Aafke A. van den Berg, Ann Mukhortava, Danah Almohdar, Jacob Ratcliffe, Mitchell Gulkis, Melike Çağlayan
This study investigates how LIG1 binds to nick DNA at the single-molecule level, revealing specific and non-specific binding dynamics and the role of the N-terminal region in nick search.
Nucleic Acids Research · Sep 20, 2024Peer-reviewedBiochemistry