Mitchell Gulkis

This study identifies AAV2's ability to bundle actin filaments, suggesting a new class of actin-binding viruses and offering insights for improving AAV gene therapy.

This study characterizes LIG1 active site mutants to show F635 and F872 residues are critical for accurate nick ligation and DNA repair.

This study investigates how LIG1 binds to nick DNA at the single-molecule level, revealing specific and non-specific binding dynamics and the role of the N-terminal region in nick search.