Surajit Chatterjee

Characterization of nick binding and sealing by LIG1 Huntington's disease-asssociated K845N variant at biochemical, structural, and single-molecule levels

This study examines how the K845N mutation in LIG1 affects nick binding and sealing using biochemical, structural, and single-molecule approaches, revealing reduced ligation efficiency and altered binding dynamics.

Single-molecule analysis of gap and nick binding by LIG1 and LIG3α at the final step of DNA repair

This study uses single-molecule techniques to compare how LIG1 and LIG3 bind and ligate gap and nick DNA substrates, revealing differences in binding dynamics and efficiency.

Biochemical, structural, and single-molecule characterization of LIG1 active site mutants demonstrate role of F635 and F872 residues for faithful ligation

This study characterizes LIG1 active site mutants to show F635 and F872 residues are critical for accurate nick ligation and DNA repair.