Microbiopsy of living mouse brain for longitudinal molecular profiling
Alexander Hoyningen, Anna Ramisch, Loelia Fellouse, Agnès Hiver, Alma Lingenberg, Christian Lüscher, Lucile Marion‐Poll
This paper introduces a minimally invasive microbiopsy technique for longitudinal molecular profiling of the living mouse brain, enabling transcriptomic and epigenomic analyses without sacrificing the animal.
bioRxiv · Jan 24, 2026 · PreprintNeuroscience