Agnès Hiver

This paper introduces a minimally invasive microbiopsy technique for longitudinal molecular profiling of the living mouse brain, enabling transcriptomic and epigenomic analyses without sacrificing the animal.

This study shows that repeated optogenetic activation of dopamine neurons induces locomotor sensitization and cross-sensitization to cocaine, demonstrating dopamine's role in behavioral plasticity.

The paper measures dopamine and serotonin release in the striatum after cocaine and neuronal stimulation, finding parallel dynamics with limited asymmetric crosstalk.