Christian Lüscher

This paper optimizes temporal interference stimulation (TIS) targeting in mice to reduce off-target effects while maintaining efficacy in the prefrontal cortex.

This study investigates how dopamine modulates striatopallidal synapses in different GPe subregions, revealing region-specific presynaptic and postsynaptic inhibition mechanisms.

This paper introduces a minimally invasive microbiopsy technique for longitudinal molecular profiling of the living mouse brain, enabling transcriptomic and epigenomic analyses without sacrificing the animal.

This study shows that repeated optogenetic activation of dopamine neurons induces locomotor sensitization and cross-sensitization to cocaine, demonstrating dopamine's role in behavioral plasticity.

The paper measures dopamine and serotonin release in the striatum after cocaine and neuronal stimulation, finding parallel dynamics with limited asymmetric crosstalk.

The paper shows that cocaine exposure causes opposing activity changes in D1R and D2R SPNs in the NAc, with ERK inhibition reducing D1R responses during sensitization.

The paper identifies increased AMPA/NMDA ratio at OFC-DS synapses and SPN activity peaks as drivers of compulsive reward seeking in mice.

This paper shows that d-amphetamine and methylphenidate increase GluA1 phosphorylation at Ser845 in mouse cerebellar Bergmann Glia Cells via norepinephrine signaling.

The paper shows that VTA dopamine neurons encode both reward prediction error and goal-directed action parameters during an operant task in mice.

The paper introduces mesoSPIM, an open-source light-sheet microscope initiative for imaging large cleared tissue samples with near-isotropic resolution.

This study shows heroin activates specific dopamine neurons in the ventral tegmental area projecting to the medial shell of the nucleus accumbens, and manipulations of these neurons affect heroin reinforcement.

This study identifies the anatomical and electrophysiological organization of PAG neurons projecting to VTA, showing their distribution and excitatory nature targeting both DA and GABA neurons.