Potency and selectivity of a novel pan-RAS inhibitor in 3D bioprinted organoid tumor models
Daniela Farias de Nóbrega, Logan C. Eiler, Parmanand Ahirwar, Urvi P. Rawal, Chelsea L. Crawford, Donald J. Buchsbaum, Adam B. Keeton, Yulia Y. Maxuitenko, Xi Chen, Gary Anthony Piazza, Allan Tsung, Karim I. Budhwani
This study evaluates the potency and selectivity of the pan-RAS inhibitor ADT-007 in 3D bioprinted organoid tumor models of KRAS-mutant and RAS wild-type colorectal cancer.
bioRxiv · Feb 25, 2025 · PreprintBioengineering