Author
Auburn UniversityORCID 0009-0003-2790-5176Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Dhana Sekhar Reddy Bandi, Ganji Purnachandra Nagaraju, Sujith Sarvesh…·Bassel F. El‐Rayes
Oral PDE10 inhibitor ADT-030 curbed KRAS-mutant pancreatic cancer growth and metastasis in mouse models, stayed active in KRAS-inhibitor-resistant cells, and shifted tumor immune profiles.
Md Yeashin Gazi, Yan Ye, Ogacheko D. Okoko…·Gang Zhou
This study shows that PDE10A inhibition with ADT-030 suppresses tumor growth by disrupting MAPK signaling and enhancing antitumor immunity through immune cell modulation.
Daniela Farias de Nóbrega, Logan C. Eiler, Parmanand Ahirwar…·Karim I. Budhwani
This study evaluates the potency and selectivity of the pan-RAS inhibitor ADT-007 in 3D bioprinted organoid tumor models of KRAS-mutant and RAS wild-type colorectal cancer.