Myofibrillar protein accumulation but reduced protein synthesis in PDCD4-depleted myotubes
Stephen Mora, Lilia Alihemmat, Logan D. Davari, Termeh Ataie, Parsa Nafari Mehranjani, Luke D. Flewwelling, Arthur J. Cheng, Olasunkanmi A. J. Adegoke
This study shows that PDCD4 depletion in myotubes increases myofibrillar protein accumulation but reduces protein synthesis, linked to metabolic changes and reduced ATP levels.
bioRxiv · Oct 24, 2025 · PreprintPhysiology