Author

Luke D. Flewwelling

York UniversityORCID 0000-0002-3841-7878Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:metabolism & bioenergetics· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Arthur J. ChengiD· 2 shared Aditya N. BrahmbhattiD· 1 shared Bianca GarlisiiD· 1 shared Brooke A. Morris· 1 shared Caroline Aitken· 1 shared Christopher G. R. PerryiD· 1 shared Jeremy A. SimpsoniD· 1 shared Jim PetrikiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersPhysiology

Arthur J. ChengORCID

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2 papers

Recent·Most cited

PhysiologybioRxivPreprintOct 24, 2025

Myofibrillar protein accumulation but reduced protein synthesis in PDCD4-depleted myotubes

Stephen Mora, Lilia Alihemmat, Logan D. Davari…·Olasunkanmi A. J. Adegoke

This study shows that PDCD4 depletion in myotubes increases myofibrillar protein accumulation but reduces protein synthesis, linked to metabolic changes and reduced ATP levels.

DOI 10.1101/2025.10.24.684280

mouseproteomics

𝕏 PostBluesky

PhysiologyMolecular MetabolismPeer-reviewedJul 17, 2025

Mitochondrial-targeted plastoquinone therapy ameliorates early onset muscle weakness that precedes ovarian cancer cachexia in mice

Luca J. Delfinis, Shahrzad Khajehzadehshoushtar, Luke D. Flewwelling…·Christopher G. R. Perry

This study shows mitochondrial-targeted plastoquinone SkQ1 reduces early muscle weakness in ovarian cancer mice by improving calcium handling and mitochondrial function, without preventing atrophy.

5 citations

mouseexperimental assay

𝕏 PostBluesky