Arthur J. Cheng

This study shows that PDCD4 depletion in myotubes increases myofibrillar protein accumulation but reduces protein synthesis, linked to metabolic changes and reduced ATP levels.

This study shows mitochondrial-targeted plastoquinone SkQ1 reduces early muscle weakness in ovarian cancer mice by improving calcium handling and mitochondrial function, without preventing atrophy.

This paper introduces a novel mouse model of ovarian cancer cachexia showing that muscle weakness and mitochondrial stress occur before metastasis and atrophy in specific muscles.