IOP-induced blood-retinal barrier compromise contributes to RGC death in glaucoma
Chi Zhang, Haeyn Lim, Jennifer D. Ballheim, Marina Simón, Rui Fu, Nicholas G. Tolman, Logan J. Horbal, Felicia A. Juarez, Qing Wang, Aakriti Bhandari, Christa L. Montgomery, Ling Zhu, Jonathan Guy Crowston, Nicolas Robine, Michael P. Fautsch, , Simon W. M. John
This study shows that elevated intraocular pressure compromises the blood-retinal barrier, leading to vascular leakage and retinal ganglion cell death in glaucoma models.
Nature Communications · Apr 8, 2026Peer-reviewedNeuroscience