Simon W. M. John

The paper uses single-cell RNA sequencing to identify age-related immune remodeling in ocular outflow tissues that may help maintain intraocular pressure.

The paper creates a multi-omics atlas of human trabecular meshwork and ciliary body cells, identifying cell types and regulatory programs linked to glaucoma.

This study shows that elevated intraocular pressure compromises the blood-retinal barrier, leading to vascular leakage and retinal ganglion cell death in glaucoma models.

The paper identifies mitochondrial dysfunction in a glaucoma model using single-cell analysis and shows that vitamin B3 treatment protects against IOP elevation.

This study shows MKK4 and MKK7 drive RGC soma and axon degeneration after glaucoma injury, while DDIT3/JUN only prevent soma loss but not axon degeneration.

The paper uses single-cell transcriptomics to characterize anterior segment development, identifying cell types, pathways, and signaling networks in trabecular meshwork and Schlemm's canal formation.

This study investigates the role of TLR4 in chronic glaucoma using a mouse model and finds no significant effect on glaucomatous progression.

The paper identifies a metabolomic signature of resilience to glaucoma in high-risk individuals and validates pyruvate's protective role in a mouse model.

The paper identifies resident tissue macrophages as critical for maintaining intraocular pressure homeostasis by regulating extracellular matrix turnover in the trabecular meshwork.

This study measures anterior and posterior chamber volumes in mice, finding the anterior chamber constitutes 47% of total aqueous humor volume, significantly different from humans, and suggests previous inflow rate estimates may be overestimated.

The paper performs transcriptomic analyses of Schlemm's canal endothelial cells to reveal their lymphatic identity, three major cell states, and interactions with trabecular meshwork cells.

The paper investigates how CyclinD2 regulates RGC neurogenesis in the mouse ciliary margin zone and shows its disruption in albinism leads to impaired binocular vision.

This study analyzes NADK2 deficiency in mouse models to identify metabolic and gene expression changes, revealing similarities and differences with another neurological disease model.

This study shows GLIS1 regulates trabecular meshwork function and intraocular pressure, with a human variant linked to glaucoma.

This study shows that genetic background affects the severity of glaucoma-related phenotypes in Lmx1b mutant mice, identifies a modifier locus on Chromosome 18, and provides strains with varying phenotypes.

The paper presents two computational methods to reduce contamination in single-cell RNA-seq data, improving clustering and biological interpretation.

This study identifies early metabolic and inflammatory changes in microglia from a glaucoma mouse model and shows radiation therapy reverses these changes.

The paper shows oral pyruvate protects against glaucomatous neurodegeneration in mice by improving bioenergetics and inhibiting mTOR.

This study shows that PRSS56 is essential for proper positioning of ocular angle structures during development, leading to angle closure and elevated intraocular pressure in mice.