Christa L. Montgomery

The paper uses single-cell RNA sequencing to identify age-related immune remodeling in ocular outflow tissues that may help maintain intraocular pressure.

This study shows that elevated intraocular pressure compromises the blood-retinal barrier, leading to vascular leakage and retinal ganglion cell death in glaucoma models.

The paper identifies mitochondrial dysfunction in a glaucoma model using single-cell analysis and shows that vitamin B3 treatment protects against IOP elevation.

The paper uses single-cell transcriptomics to characterize anterior segment development, identifying cell types, pathways, and signaling networks in trabecular meshwork and Schlemm's canal formation.

This study investigates the role of TLR4 in chronic glaucoma using a mouse model and finds no significant effect on glaucomatous progression.

The paper identifies a metabolomic signature of resilience to glaucoma in high-risk individuals and validates pyruvate's protective role in a mouse model.

This study measures anterior and posterior chamber volumes in mice, finding the anterior chamber constitutes 47% of total aqueous humor volume, significantly different from humans, and suggests previous inflow rate estimates may be overestimated.

The paper performs transcriptomic analyses of Schlemm's canal endothelial cells to reveal their lymphatic identity, three major cell states, and interactions with trabecular meshwork cells.

This study shows that genetic background affects the severity of glaucoma-related phenotypes in Lmx1b mutant mice, identifies a modifier locus on Chromosome 18, and provides strains with varying phenotypes.