Programmed Delayed Splicing: A Mechanism for Timed Inflammatory Gene Expression
Jacob S. Dearborn, Luke S. Frankiw, Damas W. Limoge, Christian Shizuo Burns, Logan Vlach, Patricia Turpin, Tylar Kirch, Zachary D. Miller, William Dowell, Sylvester Languon, Yvette Garcia-Flores, Robert C. Cockrell, David Baltimore, Devdoot S. Majumdar
The paper identifies delayed splicing as a mechanism for timed inflammatory gene expression, showing that introns with suboptimal splice donor sites can delay mRNA production and limit expression amplitude.
The Journal of Immunology · Jul 28, 2026Peer-reviewedImmunology