David Baltimore

The paper identifies delayed splicing as a mechanism for timed inflammatory gene expression, showing that introns with suboptimal splice donor sites can delay mRNA production and limit expression amplitude.

This study identifies NF-κB-driven chromatin remodeling as a mechanism for drug-induced dedifferentiation in cancer, revealing its role in promoting drug-tolerant persister states.

This study identifies Bud13 as an RNA-binding protein that reduces intron retention in Irf7, enhancing type I interferon response and antiviral defense.