Devdoot S. Majumdar

This study shows that endothelial calcium signaling spreads widely during vascular injury, but phosphatidylserine externalization remains localized, revealing spatial uncoupling between calcium signaling and phospholipid scrambling.

The paper identifies delayed splicing as a mechanism for timed inflammatory gene expression, showing that introns with suboptimal splice donor sites can delay mRNA production and limit expression amplitude.

The paper investigates PABPC1's role in alternative polyadenylation during B cell development, finding it primarily shortens and downregulates its targets in a context-dependent manner.

This study identifies XPO5 as a regulator of B cell receptor surface expression through a genome-wide CRISPRi screen, showing its role in balancing mutagenesis and DNA repair during somatic hypermutation.

The paper identifies IFI16 as a host protein interacting with SARS-CoV-2 NSP8/NSP10, showing that IFI16 promotes coronavirus infection independently of its role in type I IFN regulation.

This study develops a novel mouse model of human lung cancer cachexia that exhibits early adipose tissue wasting and metabolic reprogramming, mirroring human disease features.

The paper investigates how extracellular Ca2+ shields endothelial cells from histone-induced injury and enables membrane repair through direct interaction with histones and membrane phospholipids.

This study identifies Bud13 as an RNA-binding protein that reduces intron retention in Irf7, enhancing type I interferon response and antiviral defense.