Author

Tylar Kirch

University of Vermont

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cell-cell communication· 1 Approach:deep learning· 1

Frequent Co-Authors

Devdoot S. MajumdariD· 4 shared Jacob S. DearborniD· 4 shared Sylvester LanguoniD· 4 shared Zachary D. MilleriD· 4 shared William Dowell· 3 shared Hana PaculováiD· 2 shared James WohlschlegeliD· 2 shared Jihui ShaiD· 2 shared

Activity by Year

2026-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersImmunology

Devdoot S. MajumdarORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Programmed Delayed Splicing: A Mechanism for Timed Inflammatory Gene Expression

Jacob S. Dearborn, Luke S. Frankiw, Damas W. Limoge, Christian Shizuo Burns, Logan Vlach, Patricia Turpin, Tylar Kirch, Zachary D. Miller, William Dowell, Sylvester Languon, Yvette Garcia-Flores, Robert C. Cockrell, David Baltimore, Devdoot S. Majumdar

The paper identifies delayed splicing as a mechanism for timed inflammatory gene expression, showing that introns with suboptimal splice donor sites can delay mRNA production and limit expression amplitude.

The Journal of Immunology · Jul 28, 2026Peer-reviewedImmunology

PABPC1 Modulates Immunoglobulin pre-mRNA Alternative Polyadenylation

Zachary D. Miller, Jacob Dearborn, Ramiro Barrantes-Reynolds, Hana Paculová, Drew D. Honson, Jihui Sha, Weixian Deng, Tylar Kirch, William Dowell, Sylvester Languon, Kalev Freeman, Seth E. Frietze, James Wohlschlegel, Devdoot S. Majumdar

The paper investigates PABPC1's role in alternative polyadenylation during B cell development, finding it primarily shortens and downregulates its targets in a context-dependent manner.

bioRxiv · Apr 24, 2026 · PreprintMolecular Biology

Genome-Wide CRISPRi Screening Identifies XPO5 as a Regulator of B Cell Mutation and Fitness

Tylar Kirch, Zachary D. Miller, Jacob S. Dearborn, William G Dowell, Sylvester Languon, Hana Paculová, Jade H Cleary, Seth E. Frietze, Kalev Freeman, Devdoot S. Majumdar

This study identifies XPO5 as a regulator of B cell receptor surface expression through a genome-wide CRISPRi screen, showing its role in balancing mutagenesis and DNA repair during somatic hypermutation.

bioRxiv · Apr 24, 2026 · PreprintCell Biology

Proximity proteomics reveals a role for IFI16 during human coronavirus infection

Sylvester Languon, Ian T. Bailey, Madeleine Sorensen, Zachary D. Miller, Jihui Sha, Jacob Dearborn, William Dowell, Tylar Kirch, James Wohlschlegel, Devdoot S. Majumdar

The paper identifies IFI16 as a host protein interacting with SARS-CoV-2 NSP8/NSP10, showing that IFI16 promotes coronavirus infection independently of its role in type I IFN regulation.

bioRxiv · Apr 23, 2026 · PreprintMicrobiology