Author

Luke S. Frankiw

California Institute of Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Christian Shizuo Burns· 2 shared David BaltimoreiD· 2 shared Devdoot S. MajumdariD· 2 shared Annie MoradianiD· 1 shared Damas W. LimogeiD· 1 shared Jacob S. DearborniD· 1 shared Logan M. VlachiD· 1 shared Logan Vlach· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersImmunology

Christian Shizuo Burns

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2 papers

Recent·Most cited

Programmed Delayed Splicing: A Mechanism for Timed Inflammatory Gene Expression

Jacob S. Dearborn, Luke S. Frankiw, Damas W. Limoge, Christian Shizuo Burns, Logan Vlach, Patricia Turpin, Tylar Kirch, Zachary D. Miller, William Dowell, Sylvester Languon, Yvette Garcia-Flores, Robert C. Cockrell, David Baltimore, Devdoot S. Majumdar

The paper identifies delayed splicing as a mechanism for timed inflammatory gene expression, showing that introns with suboptimal splice donor sites can delay mRNA production and limit expression amplitude.

The Journal of Immunology · Jul 28, 2026Peer-reviewedImmunology

Bud13 Promotes a Type I Interferon Response By Countering Intron Retention in Irf7

Luke S. Frankiw, Devdoot S. Majumdar, Christian Shizuo Burns, Logan M. Vlach, Annie Moradian, Michael J. Sweredoski, David Baltimore

This study identifies Bud13 as an RNA-binding protein that reduces intron retention in Irf7, enhancing type I interferon response and antiviral defense.

Molecular Cell · Jan 10, 2019Peer-reviewedMolecular Biology