Somatic Genome Diversification and Clonal Evolution of Pathogenic B Cells in Systemic Autoimmunity
Yumika Shiba, Pathum Kossinna, Loic Cameron Caloren, Lizzy Pijpers, Xuyao Li, Arghavan Ashouri, Jianfan Nie, Dennisse Bonilla, Laura P. Whittall-García, Joan Wither, Dafna D. Gladman, Zahi Touma, Leandro Venturutti, Federico Gaiti
This study maps somatic mutations in B-cell subsets of SLE patients, finding high mutational burden in double-negative B cells linked to disease duration and therapy.
bioRxiv · Jun 11, 2026 · PreprintGenomics