Author

Jianfan Nie

University Health NetworkORCID 0009-0005-0724-0167Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Aaron Reyes· 1 shared Andrew C. Clément· 1 shared Andrew R. PepperiD· 1 shared Antonio A. HansoniD· 1 shared Arghavan AshouriiD· 1 shared Cassandra A.A. LocatelliiD· 1 shared Conor O’Dwyer· 1 shared Dafna D. GladmaniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperPhysiology

Aaron Reyes

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2 papers

Recent·Most cited

PhysiologybioRxivPreprintSep 4, 2026

Casp1 and Ripk3 are required for homeostatic insulin secretion in mice

Madison D. Girouard, Conor O’Dwyer, Cassandra A.A. Locatelli…·Morgan D. Fullerton

This study shows that deleting both Casp1 and Ripk3 in mice improves glucose-stimulated insulin secretion, independent of cell death or inflammation.

DOI 10.64898/2026.09.01.748578

mouseexperimental assay

𝕏 PostBluesky

GenomicsbioRxivPreprintJun 11, 2026

Somatic Genome Diversification and Clonal Evolution of Pathogenic B Cells in Systemic Autoimmunity

Yumika Shiba, Pathum Kossinna, Loic Cameron Caloren…·Federico Gaiti

This study maps somatic mutations in B-cell subsets of SLE patients, finding high mutational burden in double-negative B cells linked to disease duration and therapy.

DOI 10.64898/2026.06.08.730997

humanwhole-exome sequencing

𝕏 PostBluesky