Author

Yumika Shiba

University Health Network

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Genomics· 1

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Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-exome sequencing· 1

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Arghavan AshouriiD· 1 shared Dafna D. GladmaniD· 1 shared Dennisse Bonilla· 1 shared Federico GaitiiD· 1 shared Jianfan NieiD· 1 shared Joan WitheriD· 1 shared Laura P. Whittall-GarcíaiD· 1 shared Leandro VenturuttiiD· 1 shared

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Arghavan AshouriORCID

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1 paper

Recent·Most cited

GenomicsbioRxivPreprintJun 11, 2026

Somatic Genome Diversification and Clonal Evolution of Pathogenic B Cells in Systemic Autoimmunity

Yumika Shiba, Pathum Kossinna, Loic Cameron Caloren…·Federico Gaiti

This study maps somatic mutations in B-cell subsets of SLE patients, finding high mutational burden in double-negative B cells linked to disease duration and therapy.

DOI 10.64898/2026.06.08.730997

humanwhole-exome sequencing

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