Amoeboid-Mesenchymal Transition and the Proteolytic Control of Cancer Invasion Plasticity
Adam W. Olson, Jonathan Li, Xiao-Yan Li, Lana King, Long Jiang, Kalins Banerjee, Atticus J. McCoy, Mahnoor N. Gondal, Arul M. Chinnaiyan, Dorraya El‐Ashry, Evan T. Keller, Andrew J. Putnam, Stephen J. Weiss
This study identifies MMP14 as essential for cancer cell invasion through ECM barriers, showing that its proteolytic activity is required for maintaining nuclear integrity and facilitating invasion in both synthetic and human tissue models.
Proceedings of the National Academy of Sciences · Apr 10, 2026Peer-reviewedCancer Biology