Dorraya El‐Ashry

This study identifies MMP14 as essential for cancer cell invasion through ECM barriers, showing that its proteolytic activity is required for maintaining nuclear integrity and facilitating invasion in both synthetic and human tissue models.

This study shows that circulating cancer-associated fibroblasts (cCAFs) enhance breast cancer cell extravasation by promoting urokinase plasminogen activator (uPA) expression, facilitating metastasis.