Evan T. Keller

A lipid-laden macrophage niche drives immunosuppression in primary central nervous system lymphoma

This study identifies lipid-laden macrophages as an immunosuppressive niche in PCNSL, validated through spatial transcriptomics and mouse models, and shows SYK inhibition reverses their tumor-supportive activity.

SPICE: A Robust Computational Framework for Identifying Copy Number Variations in Spatial Transcriptomics

SPICE identifies somatic CNVs and ASCN profiles from spatial transcriptomics data by integrating gene expression, spatial coordinates, and SNPs to improve CNV detection accuracy.

Multi-resolution Spatial Graphical Regression Models for Hierarchical Spatial Transcriptomics Data

This paper introduces a Bayesian multi-resolution spatial graphical regression framework to infer spatially varying gene networks from hierarchical spatial transcriptomics data, showing improved network recovery and identifying key regulatory hubs in kidney cancer.

Amoeboid-Mesenchymal Transition and the Proteolytic Control of Cancer Invasion Plasticity

This study identifies MMP14 as essential for cancer cell invasion through ECM barriers, showing that its proteolytic activity is required for maintaining nuclear integrity and facilitating invasion in both synthetic and human tissue models.

STDrug enables spatially informed personalized drug repurposing from spatial transcriptomics

STDrug improves drug repurposing by integrating spatial transcriptomics with machine learning to prioritize patient-specific therapies.

A spatiotemporal atlas of orchiectomy-induced androgen deprivation-mediated modulation of cellular composition and gene expression in the mouse prostate.

This study maps the spatiotemporal changes in mouse prostate cellular composition and gene expression after orchiectomy-induced androgen deprivation, identifying new fibroblast subtypes and altered intercellular communication.

Cellular cartography reveals mouse prostate organization and determinants of castration resistance

This study maps the mouse prostate's cellular organization and identifies key determinants of castration resistance using single-cell and spatial transcriptomics.

Spatial analysis reveals a novel inflammatory tumor transition state which promotes a macrophage-driven induction of sarcomatoid renal cell carcinoma

The paper identifies a transcriptional transition state in ccRCC cells that drives sarcomatoid transformation and enhances immunotherapy response via macrophage and T-cell interactions.

Complement C3d enables protective immunity capable of distinguishing spontaneously transformed from non-transformed cells

This study shows that intracellular C3d enhances immune surveillance by inducing T cell responses against malignant plasma cells while sparing normal cells in a murine model of multiple myeloma.