Neutrophil Extracellular Trap Formation and Complement Activation Pathways Dominate Microbiota-dependent disease bias in lupus-prone female NZM2328 mice
Soumyabrata Roy, Jaisheela Vimali Irudhayaraj, Rekha Jalandra, Ping Lü, Diana-Christine Boucher, Radhika R. Gudi, Loni Carter, Caroline Westwater, Chenthamarakshan Vasu
This study shows that gut microbiota influences lupus-like disease outcomes differently in male and female NZM2328 mice, with females showing higher NET and complement pathway activation leading to disease susceptibility.
bioRxiv · Jul 1, 2026 · PreprintImmunology