Author

Lorena de Oñate

Innovative Genomics Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:clustering· 1 Assay:CRISPR screen· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

David N. NguyeniD· 1 shared Joseph J. MuldooniD· 1 shared Justin EyquemiD· 1 shared Kunica AsijaiD· 1 shared Madalena Castro· 1 shared Netravathi KrishnappaiD· 1 shared Ross C. WilsoniD· 1 shared Srishti U. SahuiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperBioengineering

David N. NguyenORCID

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1 paper

Recent·Most cited

Peptide-enabled ribonucleoprotein delivery for CRISPR engineering (PERC) in primary human immune cells and hematopoietic stem cells

Srishti U. Sahu, Madalena Castro, Joseph J. Muldoon, Kunica Asija, Stacia K. Wyman, Netravathi Krishnappa, Lorena de Oñate, Justin Eyquem, David N. Nguyen, Ross C. Wilson

This paper introduces PERC, a method for efficient CRISPR editing in primary human immune cells and HSPCs using a peptide reagent, achieving over 90% editing efficiency without specialized equipment.

Nature Protocols · Mar 3, 2025Peer-reviewedBioengineering