Author

Lorie Chen Cai

Tianjin Medical University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Zhigang CaiiD· 3 shared Ge DongiD· 2 shared Hang He· 2 shared Hongxi Zhou· 2 shared Huaquan WangiD· 2 shared Yuchen Wen· 2 shared Yunxi Ma· 2 shared Baobing ZhaoiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersImmunology

Zhigang CaiORCID

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3 papers

Recent·Most cited

Disturbing immune homeostasis by neutrophil loss of Uba1 induces VEXAS-like autoinflammatory disease in mice

Ge Dong, Jingjing Liu, Hongxi Zhou, Wenyan Jin, Yuchen Wen, Zhiqin Wang, Keyao Xia, Jianlin Zhang, Li Ma, Yunxi Ma, Lorie Chen Cai, Qiufan Zhou, Huaquan Wang, Wei Wei, Ying Fu, Zhigang Cai

This study shows that neutrophil loss of Uba1 in mice causes VEXAS-like autoinflammatory disease, with symptoms including increased neutrophils, cytokines, and vacuoles.

Journal of Clinical Investigation · Sep 4, 2025Peer-reviewedImmunology

Depicting pathogenesis of osteomyelitis by single cell RNA-sequencing and an involvement of Morrbid in the autoinflammatory disease

Qingran Huo, Jiayu Ding, Hongxi Zhou, Yue Wang, Shanshan Wang, Hang He, Lorie Chen Cai, Jingjing Liu, Ge Dong, Zhigang Cai

This study uses scRNA-seq to show that loss of Morrbid reduces osteoclasts and inflammation in a mouse model of CRMO, suggesting it as a therapeutic target for osteomyelitis.

Disease Models & Mechanisms · Jun 12, 2025Peer-reviewedImmunology

Computing hematopoiesis plasticity in response to genetic mutations and environmental stimulations

Yuchen Wen, Hang He, Yunxi Ma, Dengyi Bao, Lorie Chen Cai, Huaquan Wang, Yanmei Li, Baobing Zhao, Zhigang Cai

This study introduces a computational pipeline to quantify hematopoietic cell plasticity using single-cell RNA-seq data and identifies factors influencing plasticity under genetic and environmental stress.

Life Science Alliance · Nov 13, 2024Peer-reviewedDevelopmental Biology