Ge Dong

The paper introduces CauNagi, a causal machine learning tool, to identify causal drivers of VEXAS syndrome using single-cell transcriptomic data, revealing key regulatory hubs involved in myeloid dysfunction.

This paper uses single-cell RNA sequencing to analyze cellular changes in Lynch Syndrome colorectal cancer, identifying cancer stem cells, immune infiltration, and mutation burden during malignant transition.

This study shows that neutrophil loss of Uba1 in mice causes VEXAS-like autoinflammatory disease, with symptoms including increased neutrophils, cytokines, and vacuoles.

This study uses scRNA-seq to show that loss of Morrbid reduces osteoclasts and inflammation in a mouse model of CRMO, suggesting it as a therapeutic target for osteomyelitis.

This study shows that Zbtb33 knockout in mice does not induce clonal hematopoiesis but influences tumor immunity and the tumor microenvironment.