Disturbing immune homeostasis by neutrophil loss of Uba1 induces VEXAS-like autoinflammatory disease in mice
Ge Dong, Jingjing Liu, Hongxi Zhou, Wenyan Jin, Yuchen Wen, Zhiqin Wang, Keyao Xia, Jianlin Zhang, Li Ma, Yunxi Ma, Lorie Chen Cai, Qiufan Zhou, Huaquan Wang, Wei Wei, Ying Fu, Zhigang Cai
This study shows that neutrophil loss of Uba1 in mice causes VEXAS-like autoinflammatory disease, with symptoms including increased neutrophils, cytokines, and vacuoles.
Journal of Clinical Investigation · Sep 4, 2025Peer-reviewedImmunology