Persistent Activation of Endothelial Cells is Linked to Thrombosis and Inflammation in Cerebral Cavernous Malformation Disease
Helios Gallego-Gutiérrez, Eduardo Frías-Anaya, Cassandra Bui, Louie Zhao, Emily Hsu, Hannah S. Indralingam, Jakob Körbelin, JoAnn Trejo, Jeffrey D. Steinberg, Nathan R. Zemke, Miguel Alejandro Lopez‐Ramirez
This paper identifies JUNB as a key driver of chronic brain vascular inflammation in CCM disease through multi-omic analysis of endothelial cell activation.
bioRxiv · Jun 29, 2025 · PreprintGenomics