Helios Gallego-Gutiérrez

This paper identifies metformin as a potential drug for long-term treatment of cerebral cavernous malformations using AI, high-throughput screening, and animal models.

This paper identifies JUNB as a key driver of chronic brain vascular inflammation in CCM disease through multi-omic analysis of endothelial cell activation.

This study shows that silencing KRIT1 in endothelial cells under disturbed flow restores KLF2 and KLF4 expression, mimicking the transcriptomic profile of cells under laminar flow.

This study shows that CCM lesions in mice cause behavioral impairments linked to neuroinflammation, affecting motor coordination and memory.

This study identifies neuroinflammatory astrocytes and CCM endothelium interactions that drive leukocyte recruitment and immunothrombosis in cerebral cavernous malformations, while showing that targeting endothelial NF-kB may have harmful effects.