JoAnn Trejo

This study identifies the molecular mechanisms underlying signaling bias in PAR1, showing distinct roles of GRK5 and β-arrestin-2 in thrombin- and APC-induced responses.

This paper identifies metformin as a potential drug for long-term treatment of cerebral cavernous malformations using AI, high-throughput screening, and animal models.

This study shows APC activates PAR1 through βarr2 and c-Src to phosphorylate Cav1 and alter its interactions with PAR1 and GRK5 in endothelial cells.

This paper identifies JUNB as a key driver of chronic brain vascular inflammation in CCM disease through multi-omic analysis of endothelial cell activation.