Essential regulation of heparan sulfate proteoglycan signalling controls cell behaviour to support cardiac development
Andia N. Redpath, Irina-Elena Lupu, Louis Haffreingue, Quang Dang, Ian R McCracken, Tamara Carsana, Toin H. Van Kuppevelt, Joaquim Miguel Vieira, Nicola Smart
This study shows SULF1, expressed in the epicardium, regulates HSPG sulfation to control cardiac development by modulating signaling and cell fate.
bioRxiv · Jul 23, 2025 · PreprintDevelopmental Biology